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Does Effexor cause joint pain?

Author

Noah Mitchell

Published Apr 23, 2026

10% of folks taking venlafaxine experience joint pain.

Then, does Effexor cause inflammation?

Conclusion: These results demonstrated that venlafaxine has potent anti-inflammatory effect which is related to the peripheral and central effects of this drug.

Also, does Effexor help with joint pain? These drugs may also be used to help relieve chronic pain: Serotonin and norepinephrine reuptake inhibitors (SNRIs). Some SNRIs , such as venlafaxine (Effexor XR), duloxetine (Cymbalta, Drizalma Sprinkle), milnacipran (Savella) and desvenlafaxine (Pristiq), may help relieve chronic pain.

Considering this, what are the most common side effects of Effexor?

The more common side effects of Effexor XR can include:

  • dry mouth.
  • sleepiness.
  • loss of appetite.
  • erectile dysfunction.
  • abnormal ejaculation.
  • loss of libido (sex drive) in men and women.
  • weakness.
  • dizziness.

Why has Effexor has been discontinued in the US?

Pfizer discontinued the original version of Effexor in part because it required two or three doses per day while the extended-release version allows for a single daily dose for most patients. Suggested dosages for venlafaxine are significantly higher compared to many SSRI antidepressants.

Related Question Answers

Will effexor cause weight gain?

While experts may not be certain about why antidepressants cause weight gain, they do know that switching drugs may make a difference. Some antidepressants may be less likely to affect weight. Effexor and Serzone generally do not cause weight gain, while Wellbutrin can cause weight loss.

Can Effexor cause long term damage?

Effexor (Venlafaxine) Long-Term Effects

The FDA reports people taking antidepressants are 15 times more likely to commit suicide. Long-term use may also closely be associated with type 2 diabetes, according to the Journal of Clinical Psychiatry.

Can I stop taking Effexor 37.5 cold turkey?

You should not quit Effexor cold turkey. Doing so can result in withdrawal symptoms. Instead, it is recommended that you slowly taper off Effexor under a doctor's supervision.

Does Effexor affect memory?

All drugs that depress signaling in the CNS can cause memory loss. Alternatives: Many patients with seizures do well on phenytoin (Dilantin), which has little if any impact on memory. Many patients with chronic nerve pain find that venlafaxine (Effexor) — which also spares memory — alleviates their pain.

Does Effexor cause weakness?

If any of these effects persist or worsen, tell your doctor promptly. Tell your doctor right away if any of these unlikely but serious side effects occur: easy bruising/bleeding, decreased interest in sex, changes in sexual ability, muscle cramps/weakness, shaking (tremor).

Is Effexor bad for your liver?

Cases of acute and prolonged or severe liver injury have been reported in patients receiving venlafaxine, but there have been no convincing instances of acute liver failure due to venlafaxine or desvenlafaxine therapy in the published literature.

Is it okay to take Effexor at night?

Extended release tablets and capsules are released into your system gradually. You will usually take 75mg extended release tablets or capsules once a day. You can choose to take them at any time as long as you stick to the same time every day. If you have trouble sleeping, it's best to take it in the morning.

Does Effexor cause itching?

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Why is Effexor withdrawal so bad?

Because of the drug's profound impact on the brain's chemistry, stopping the medication can lead to Effexor withdrawal, causing symptoms like nausea, vomiting and mood swings. If you have been prescribed the drug, here's what you need to know.

What happens when you stop taking Effexor?

Missing doses of venlafaxine may increase your risk for relapse in your symptoms. Stopping venlafaxine abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Can you drink coffee while taking venlafaxine?

Venlafaxine produced a significant antinociceptive effect at 30 and 45 min and the effect decreased at 60 min. Caffeine alone showed no significant antinociceptive effect at the applied dose however, it significantly antagonized the antinociceptive effect of venlafaxine at 30 min.

What time of day should I take Effexor?

The extended-release capsule is usually taken once daily in the morning or evening with food. Take venlafaxine at around the same time(s) every day.

Does venlafaxine calm you down?

Venlafaxine is used to treat depression, anxiety, panic attacks, and social anxiety disorder (social phobia). It may improve your mood and energy level and may help restore your interest in daily living. It may also decrease fear, anxiety, unwanted thoughts, and the number of panic attacks.

Does effexor xr cause weight loss?

Effexor and Effexor XR may cause weight loss. This weight loss is usually small. Talk to your doctor about this if you're concerned or if you start losing too much weight. Alcohol can increase the feeling of drowsiness this medication may cause.

What can you not take with venlafaxine?

Venlafaxine may cause a serious condition called serotonin syndrome if taken together with certain medicines. Do not use venlafaxine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St.

Why does Effexor make me sweat?

Tricyclic antidepressants like amitriptyline (Amitril, Elavil) and nortriptyline (Pamelor) and serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine (Cymbalta) and venlafaxine (Effexor) also cause excess sweating. Why? SSRIs increase serotonin levels in the brain.

What is the best antidepressant for weight loss?

"We found that bupropion is the only antidepressant that tends to be linked to weight loss over 2 years," study leader David Arterburn, MD, Group Health Research Institute, Seattle, Washington, said in a Group Health Research Institute news release.

Is there a medication that treats both depression and pain?

Tricyclic antidepressants like amitriptyline and nortriptyline (Pamelor), and selective serotonin reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor XR) treat both depression and chronic pain.

Can Effexor cause nerve pain?

Although venlafaxine was generally reasonably well tolerated, there was some evidence that it can precipitate fatigue, somnolence, nausea, and dizziness in a minority of people. Background: Neuropathic pain, which is caused by nerve damage, is increasing in prevalence worldwide.

Can Antidepressants Help Arthritis Pain?

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today.

Does venlafaxine help fibromyalgia?

The SNRIs used for fibromyalgia include duloxetine (Cymbalta), Milnacipran (Savella) and venlafaxine (Effexor XR). Benefits and Risks: SNRIs protect the level of “feel good” chemicals (such as serotonin) available to the brain to help relieve depression, anxiety and pain.

What does nerve pain feel like?

People with nerve pain feel it in different ways. For some, it's a stabbing pain in the middle of the night. For others, symptoms can include a chronic prickling, tingling, or burning they feel all day. Uncontrolled nerve pain can be hard to bear.

Which is better for pain gabapentin or amitriptyline?

Both gabapentin and amitriptyline provided effective pain control in peripheral neuropathic pain. Additionally gabapentin was more effective especially in paroxysmal shooting pain than other pain qualities. And also gabapentin was tolerated well.

What antidepressants help nerve pain?

The most efficacious antidepressants for the treatment of neuropathic pain appear to be the tertiary-amine TCAs (amitriptyline, doxepin, imipramine), venlafaxine, bupropion, and duloxetine. These appear to be closely followed in efficacy by the secondary-amine TCAs (desipramine, nortriptyline).

What does Effexor XR do to the brain?

Venlafaxine works by increasing serotonin levels, norepinephrine, and dopamine in the brain by blocking transport proteins and stopping its reuptake at the presynaptic terminal.

Is Effexor stronger than Prozac?

In a study on patients who suffer from major depression, the drug Effexor was more likely than Prozac or Zoloft to result in full recovery. Researchers suspect Effexor is more effective because it acts on two different brain chemicals that transmit messages and are thought to control mood.

What is a brain zap?

Brain zaps are electrical shock sensations in the brain. They can happen in a person who is decreasing or stopping their use of certain medications, particularly antidepressants. Brain zaps are not harmful and will not damage the brain. However, they can be bothersome, disorienting, and disruptive to sleep.

Is Effexor a psychotropic medication?

Effexor and Effexor XR (venlafaxine) – an antidepressant of the SNRI class. Elavil (amitriptyline) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain.